San Francisco 49ers
NFC West · 2025 record 12-5
Schedule & lines
| Wk | Opp | Result | Spread | Total |
|---|---|---|---|---|
| 1 | @ SEA | W 17-13 | +2.5 | 43.5 |
| 2 | @ NO | W 26-21 | +3 | 40.5 |
| 3 | vs ARI | W 16-15 | +1.5 | 44.5 |
| 4 | vs JAX | L 21-26 | +3.5 | 45.5 |
| 5 | @ LA | W 26-23 | -8.5 | 43.5 |
| 6 | @ TB | L 19-30 | -3.5 | 46.5 |
| 7 | vs ATL | W 20-10 | +1.5 | 46.5 |
| 8 | @ HOU | L 15-26 | -2.5 | 41.5 |
| 9 | @ NYG | W 34-24 | +2.5 | 47.5 |
| 10 | vs LA | L 26-42 | -5.5 | 49.5 |
| 11 | @ ARI | W 41-22 | +3.5 | 48.5 |
| 12 | vs CAR | W 20-9 | +7.5 | 48.5 |
| 13 | @ CLE | W 26-8 | +5.5 | 35.5 |
| 15 | vs TEN | W 37-24 | +12.5 | 44.5 |
| 16 | @ IND | W 48-27 | +4.5 | 46.5 |
| 17 | vs CHI | W 42-38 | +3.5 | 51.5 |
| 18 | vs SEA | L 3-13 | -2.5 | 47.5 |